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Filtered Search Results
Medchemexpress LLC Methyl nicotinate | 93-60-7 | 99.95% | 25 G
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Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator with analgesic activity. It causes local skin erythema when applied topically and is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain.
- Orally active vasodilator.
- Exhibits analgesic activity.
- Causes local skin erythema when applied topically.
- Used as an active ingredient in over-the-counter topical preparations for muscle and joint pain research.
- Shows peripheral and central antialgesic effects in mice.
- Demonstrates a vasodilatory effect in egg embryo eggs.
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Medchemexpress LLC 3-Chloroindole | 16863-96-0 | >98.4% | C8H6ClN | 250 MG
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3-Chloroindole is a natural product derived from marine sources, specifically found in Ptychodera flava. It is classified as an indole alkaloid, and it is also noted as being isolated from microorganisms such as Hygrophorus paupertinus. This compound is intended for research use only.
- Origin: natural product derived from marine sources and microorganisms
- Appearance: solid
- Color: yellow to brown
- Molecular formula: C8H6ClN
- Molecular weight: 151.60
- Storage (solid): -20°C, sealed storage, away from moisture
- Storage (in solvent): -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture)
- Solubility in DMSO: 100 mg/mL (659.65 mM) with ultrasonic assistance, recommends using newly opened DMSO due to hygroscopic nature
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Medchemexpress LLC Tesirine intermediate-1 | 1430738-05-8 | 99.4% | C28H48N2O7Si2 | 250 MG
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Tesirine intermediate-1 is an intermediate in the synthesis of Tesirine, a pyrrole benzodiazepine (PBD) dimer that acts as a DNA small channel crosslinker. This compound exhibits strong cytotoxicity and is utilized for synthesizing Antibody-Drug Conjugates (ADCs) whose payloads demonstrate potent anticancer cell activity.
- Intermediate for advanced chemical synthesis
- Functions as a pyrrole benzodiazepine (PBD) dimer
- Acts as a DNA small channel crosslinker
- Exhibits strong cytotoxicity
- Key component for Antibody-Drug Conjugate (ADC) synthesis
- Payloads demonstrate potent anticancer cell activity
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Medchemexpress LLC (S)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate | 1000414-38-9 | 98.8% | C11H12O4 | 250 MG
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(S)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate is a chemical compound provided by MedChemExpress, catalog number HY-76785. Primarily used for laboratory research and the manufacture of substances, it is supplied as a solid with a purity of 98.8%.
- For laboratory chemicals and substance manufacturing.
- Supplied as a solid.
- Purity of 98.8%.
- Powder storage: -20°C for 3 years, 4°C for 2 years.
- In-solvent storage: -80°C for 6 months, -20°C for 1 month.
- Room temperature shipping for less than 2 weeks.
- Harmful if swallowed, causes skin and serious eye irritation.
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Medchemexpress LLC Moschamine | 193224-22-5 | 98.1% | 352.38 g/mol | C20H20N2O4 | 250 MG
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Moschamine is an endogenous metabolite supplied for research use that inhibits excessive mitochondrial superoxide production. It is provided as a solid for in vitro research applications and is not for human or clinical use.
- Inhibits excessive mitochondrial superoxide production.
- High reported purity of 98.1%.
- Molecular weight 352.38 g/mol and formula C20H20N2O4.
- Soluble in DMSO at approximately 100 mg/mL; ultrasonic assistance may be required.
- Stable as a solid at room temperature (3 years); in solvent: -80°C (2 years), -20°C (1 year).
- Available in multiple pack sizes, including a 250 mg vial for convenient handling.
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Medchemexpress LLC Hemagglutinin protein (H4N2, ADN78261) | 10 UG
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Recombinant hemagglutinin H4 protein derived from Influenza A H4N2 (accession ADN78261). The protein is expressed in Sf9 insect cells, carries a C-terminal His tag, and is supplied as a filtered solution in 20 mM Tris, 500 mM NaCl, pH 8.0, 10% glycerol. Endotoxin is specified as <1 EU/μg. Intended for research use; aliquot and avoid repeated freeze-thaw cycles.
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Medchemexpress LLC 2,4-dichlorophenoxyacetic acid | 94-75-7 | 99.9% | 221.04 | 250 MG
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2,4-D (Standard) is an analytical standard intended for research and analytical applications. Also known as 2,4-dichlorophenoxyacetic acid, it acts as a selective herbicide for broad-leaved weed control. This compound induces apoptosis and inhibits DNA and protein synthesis, preventing normal plant growth and development.
- Analytical standard for research and analytical applications
- Selective herbicide for broad-leaved weed control
- Induces apoptosis and inhibits DNA and protein synthesis
- Used in qualitative, quantitative and methodological research experiments in HPLC, GC, and MS
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Medchemexpress LLC N-cyano-4-dimethylaminopyridinium tetrafluoroborate | 59016-56-7 | 98.0% | 234.99 | 250 MG
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CDAP is an organic cyanylating reagent used for preparing solid-phase affinity reagents, modifying protein thiols, and delivering nucleotides. It also activates polysaccharides with various chemical properties and can be used to create conjugate vaccines and other immune reagents.
- Prepares solid-phase affinity reagents.
- Modifies protein thiols.
- Delivers nucleotides.
- Activates polysaccharides with various chemical properties.
- Creates conjugate vaccines and other immune reagents.
- Activates a wide range of acidic, neutral, and other classes of polysaccharides.
- Allows direct conjugation of proteins to activated polysaccharides without additional spacer molecules.
- Simplifies the preparation of conjugate vaccines.
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Medchemexpress LLC 2-Ethyl-6-methylaniline-d13 | 1219794-93-0 | 98.6% | 148.29 | 25 MG
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2-Ethyl-6-methylaniline-d13 is the deuterium labeled 2-Ethyl-6-methylaniline. It serves as a tracer and an internal standard for quantitative analysis. The incorporation of stable heavy isotopes into drug molecules, known as deuteration, aids in quantitation during drug development and can influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes into drug molecules.
- Aids in quantitation during drug development.
- Potential to affect pharmacokinetic and metabolic profiles of drugs.
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Medchemexpress LLC KIF18A-IN-6 | 2914879-10-8 | C28H37N3O5S2 | 250 MG
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KIF18A-IN-6 (Compound 134) is an orally active KIF18A inhibitor with an IC50 of 0.016 μM against KIF18A microtubule-dependent ATPase activity. It demonstrates anti-proliferative effects on JIMT-1, HCC-15, and NIH-OVCAR3 cells in vitro and exhibits significant tumor growth inhibition in HCC15 and OVCAR3 xenograft models in mice. This product is for research use only.
- Orally active KIF18A inhibitor
- High potency against KIF18A microtubule-dependent ATPase activity (IC50 of 0.016 μM)
- Demonstrates anti-proliferative effects on cells in vitro
- Exhibits significant tumor growth inhibition in xenograft models in mice
- Multiple packaging options cater to different research needs
- Comprehensive documentation ensures quality assurance and provides essential information for researchers
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Medchemexpress LLC Methyl vanillate | 3943-74-6 | MFCD00008438 | 99.9% | C9H10O4 | 5 G
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Methyl vanillate, a benzoate ester and plant metabolite found in Oryza sativa Linn., acts as a Wnt/β-catenin pathway activator. It also functions as an antioxidant and is intended for research use only. This compound exhibits diverse biological activities, making it valuable for various research applications.
- Acts as a Wnt/β-catenin pathway activator
- Functions as an antioxidant and plant metabolite
- Derived from Oryza sativa Linn.
- Enhances expression and nuclear translocation of β-catenin
- Elevates ALP activity in calvarial osteoblasts
- Demonstrates anticancer activity in some cell lines
- Exhibits anti-allergic activity
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Medchemexpress LLC Methyl 4-boronobenzoate | 99768-12-4 | 179.97 | 25 G
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Methyl 4-boronobenzoate, also known as 4-Methoxycarbonylbenzeneboronic acid, is a biochemical reagent used as a biological material or organic compound in life science research. It should be stored as powder at -20°C for 3 years or 4°C for 2 years. In solvent, store at -80°C for 6 months or -20°C for 1 month.
- Used in tandem-type Pd(II)-catalyzed oxidative Heck reactions.
- A reagent for intramolecular CH amidation sequences.
- Employed in copper-mediated ligandless aerobic fluoroalkylation of arylboronic acids.
- Applicable in one-pot ipso-nitration of arylboronic acids.
- Used in palladium-phosphine-catalyzed Suzuki-Miyaura coupling.
- Employed in the preparation of biaryls via nickel-catalyzed Suzuki-Miyaura cross-coupling.
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Medchemexpress LLC Methanesulfonothioic acid, S-methyl ester | 2949-92-0 | 126.20 | 25 G
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S-Methyl thiomethanesulfonate (MMTS) is a sulfur-containing volatile organic compound produced by plants and bacteria and is an effective anti-oomycete agent.
- Effective anti-oomycete agent.
- Sulfur-containing volatile organic compound.
- Produced by plants and bacteria.
- Molecular weight: 126.20.
- Purity: 99.9%.
- Appearance: Colorless to light yellow liquid.
- Pure form storage: -20°C for 3 years, 4°C for 2 years.
- In solvent storage: -80°C for 6 months, -20°C for 1 month.
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Medchemexpress LLC 5-methyl-2-(pyrimidin-2-yl)benzoic acid | 1088994-22-2 | MFCD14706695 | 214.22 | 50 G
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5-methyl-2-(pyrimidin-2-yl)benzoic acid is a chemical intermediate primarily utilized in the synthesis of anticancer drugs. This compound is typically found as a white to off-white solid.
- White to off-white solid appearance
- Molecular formula C12H10N2O2
- Molecular weight 214.22
- Boiling point 316 °C
- Density 1.260
- Flash point 145 °C
- Heavy atoms count: 16
- Rotatable bond count: 2
- Number of rings: 2
- Polar surface area: 63 Å2
- Hydrogen bond acceptors count: 4
- Hydrogen bond donors count: 1
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Medchemexpress LLC TEPP-46 (ML-265) | 1221186-53-3 | 99.9% | 372.46 | 250 MG
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TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC50 of 92 nM, demonstrating minimal to no effect on PKM1, PKL, and PKR. It is intended for research use only.
- Potent and selective pyruvate kinase M2 (PKM2) activator
- AC50 of 92 nM for PKM2
- Shows minimal effect on PKM1, PKL, and PKR
- Exhibits good oral bioavailability, low clearance, and long half-life
- Achieves maximal PKM2 activation in A549 xenograft tumors
- Decreases intracellular acetyl-coA, lactate, ribose phosphate, and serine
- Inhibits LPS-induced Hif-1α and IL-1β, downregulating M1 markers
- Significantly inhibits FSL-1 and CpG-induced Il1b mRNA expression
- Inhibits Mtb-induced Il1b mRNA and boosts Il10 mRNA levels
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